P110
About this Product
- SKU:
- PP-090
- Additional Names:
- P110, PP-090, YGRKKRRQRRRGGDLLPRGS-NH2
- Extra Details:
- P110 inhibits Drp1 enzyme activity and blocks the Drp1/Fis1 (Dynamin related protein 1/fission 1) interaction in vitro and in cultured neurons, but has no effect on the interaction between Drp1 and other mitochondrial adaptors. In Parkinson's disease models P110 is neuroprotective by inhibiting mitochondrial fragmentation and reactive oxygen species (ROS) production and subsequently improving mitochondrial membrane potential and mitochondrial integrity. P110 increases neuronal cell viability by reducing apoptosis and autophagic cell death, and reduces neurite loss of primary dopaminergic neurons.
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 2411.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. <strong>126</strong> 789 PMID: 23239023</p><p>Joshi et al (2018) Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget<strong> 9 </strong>6128</p><p>Iqbal et al (2018) A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly. Sci Rep <strong>11</strong> 4567 https://doi.org/10.1038/s41598-021-84168-y<br></p>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C100H179N45O25
