Bid BH3
About this Product
- SKU:
- PP-080
- Additional Names:
- Bid BH3 peptide, BIDBH3
- Extra Details:
- Bid BH3 peptide is a fragment derived from the BH3 domain of the pro-apoptotic protein Bid (BH3-interacting domain death agonist). Bid is a member of the BH3-only subset of the BCL-2 family of proteins that are critical control points in apoptosis and Bid is the first of the BH3 subset reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax and the BH3 peptide domain, excised from the entire BH3-only molecule, can function as a specific death ligand itself
- Molecular Weight:
- 2309.59
- Purity:
- >95% by hplc
- References:
- <p>Letai et al (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics, Cancer Cell<strong> 2</strong>(3) 183 <a href="https://pubmed.ncbi.nlm.nih.gov/12242151/" target="_blank" rel="nofollow">PMID: 12242151</a></p><p>Billen et al (2008) Bid: a Bax-like BH3 protein. Oncogene<strong> 27</strong> S93 <a href="https://pubmed.ncbi.nlm.nih.gov/19641510/" target="_blank" rel="nofollow">PMID: 19641510</a></p><p>Jeng et al (2018) BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. Curr Opin Physiol. <strong>3</strong> 71 <a href="https://pubmed.ncbi.nlm.nih.gov/30334018/" target="_blank" rel="nofollow">PMID: 30334018</a></p>
- Sequence:
- H-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C95H161N3 O32S