Bim BH3
About this Product
- SKU:
- PP-070
- Additional Names:
- Peptide IV, Bim BH3 peptide
- CAS Number:
- 721885-31-0
- Extra Details:
- Bim BH3 is a 26-residue fragment from the BH3 only protein Bim. BH3 only proteins are pro-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development, tissue homeostasis and immunity. The mammalian BH3-only proteins include Bad, Bid, Bik/NBK, Bim/Bod, Bmf, Hrk/DP5, Noxa and Puma/BBC3. Bim BH3 binds to Bcl-2, Bcl-xL and Mcl-1 with very hig affinity.
- Molecular Weight:
- 3269.69
- Purity:
- >95% by hplc
- References:
- <p>Zhong et al (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell <strong>121</strong>(7) 1085 <a href="https://pubmed.ncbi.nlm.nih.gov/15989957/" target="_blank" rel="nofollow">PMID: 15989957</a></p><p>Giam et al (2008) BH3-only proteins and their roles in programmed cell death. Oncogene <strong>27</strong> S128 <a href="https://pubmed.ncbi.nlm.nih.gov/19641498/" target="_blank" rel="nofollow">PMID: 19641498</a></p><p>Lee et al (2009), High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL. Angewandte Chemie International Edition <strong>48</strong> 4318 <a href="https://pubmed.ncbi.nlm.nih.gov/19229915/" target="_blank" rel="nofollow">PMID: 19229915</a></p>
- Sequence:
- H-Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C145H222N44O41S