PUMA BH3
About this Product
- SKU:
- PP-050
- Additional Names:
- PUMA BH3 peptide|PUMA BH3 peptide, PP-050, EEQWAREIGAQLRRMADDLNAQYER
- Extra Details:
- PUMA BH3 is a sequence derived from the BH3 domain of the BH3-only protein PUMA (p53 up-regulated modulator of apoptosis]. PUMA, also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein and member of the Bcl-2 protein family. Bcl-2 family proteins regulate the mitochondrial apoptosis pathway by controlling mitochondrial outer membrane permeabilization. The BCL2 protein family is divided into three subfamilies: antiapoptotic BCL2 family proteins, including BCL2, BCLxL, and MCL1; proapoptotic multi-domain BCL2 family proteins, including BAK, BAX, and BOK, and proapoptotic BH3-only proteins, including BIM, PUMA, BID, BAD, NOXA, BMF, HRK, and BIK. PUMA acts as a key mediator of cytosolic proapoptotic p53 function by freeing cytosolic p53 from inactive complexes with BCL-xL
- Immunogen:
- Protein-protein interactions
- Molecular Weight:
- 3049.33
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Cartron et al (2004) The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA. Molecular Cell, <strong>16</strong>(5) 807 https://doi.org/10.1016/j.molcel.2004.10.028.</p><p>Fisher et al (2008) Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS <strong>105(</strong>51) 20327 https://doi.org/10.1073/pnas.0808036105</p><p>Ye et al (2020) Characterization of an alternative BAK-binding site for BH3 peptides. Nat Commun <strong>11 </strong>3301 https://doi.org/10.1038/s41467-020-17074-y<br></p>
- Sequence:
- H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C128H202N42O43S
