SRC-1 (676-700), biotinylated
About this Product
- SKU:
- PP-020
- Additional Names:
- Biotin-CPSSHSSLTERHKILHRLLQEGSPS-OH, Biotin-CPSSHSSLTERHKILHRLLQEGSPS, CPSSHSSLTERHKILHRLLQEGSPS, SRC-1 (676-700), biotinylated, transcriptional coregulatory protein human nuclear receptor coactivator SRC-1, AlphaScreen, time-resolved fluorescence (TRF), time-resolved fluorescence energy transfer, TR-FRET, assays, nuclear receptors, ROR family proteins RORA Alpha, RORB Beta and RORI³t, farnesoid X receptor, FXR, human PPARA Alpha, PPARI³, PPARD Delta, PP-020|Biotin-SRC-1, Biotinylated steroid receptor coactivator-1 peptide
- Conjugate:
- Biotin
- Extra Details:
- SRC-1 (676-700), biotinylated, also known as biotin-SRC-1, or biotinylated steroid receptor coactivator-1 peptide, is a biotinylated 25-mer peptide derived from amino acids 676-700 of the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1. SRC-1 (676-700), biotinylated has been used in AlphaScreen, time-resolved fluorescence (TRF), and time-resolved fluorescence energy transfer (TR-FRET) assays for various nuclear receptors including assays for the ROR family proteins RORA Alpha, RORB Beta and RORI³t, a farnesoid X receptor (FXR) assay, and human PPARA Alpha, PPARI³, and PPARD Delta assays. SRC-1 (676-700), biotinylated contains a covalently bonded N-terminal biotin tag that can be used for detection and purification.
- Immunogen:
- Nuclear receptor modulators
- Molecular Weight:
- 3127.22
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Wu et al (2003) Comparison of Assay Technologies for a Nuclear Receptor Assay Screen Reveals Differences in the Sets of Identified Functional Antagonists. J. Biomol. Screen.<strong> 8</strong>(4) 381 doi:10.1177/1087057103256466 </p><p>Chen et al (2010) Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys, Endocrinology <strong>151</strong>(7) 3115 https://doi.org/10.1210/en.2009-1366 </p><p>Yang et al (2019) Discovery of betulinaldehyde as a natural RORγt agonist. Fitoterapia <strong>137</strong> 104200 https://doi.org/10.1016/j.fitote.2019.104200</p>
- Sequence:
- Biotin-Cys-Pro-Ser-Ser-His-Ser-Ser-Leu-Thr-Glu-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water and physiological buffers
- Formula:
- C128H209N41O40S2
