Bradykinin
Product Sizes
Bradykinin
£118.00
PN-210
About this Product
- SKU:
- PN-210
- CAS Number:
- 58-82-2
- Extra Details:
- Bradykinin is the endogenous agonist for the bradykinin receptor and is a proinflammatory peptide. Bradykinin acts through two GPCRs, the B1 receptor, which is expressed as a result of tissue injury and has a role in chronic pain and inflammation, and the B2 receptor, which is constitutively expressed and is responsible for bradykinin's vasodilatory role. Bradykinin has selectivity for B2 over B1 receptors. In pain, bradykinin sensitises TRPV1 receptors.
- Molecular Weight:
- 1060.22
- Purity:
- >95% by HPLC
- References:
- <p>Regoli et al (1998) Bradykinin receptors and their antagonists. Eur.J.Pharmacol. <strong>348</strong> 1 <a href="https://pubmed.ncbi.nlm.nih.gov/9650825/" target="_blank" rel="nofollow">PMID: 9650825</a></p><p>Leeb-Lundberg et al (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. <strong>57</strong> 27<a href="https://pubmed.ncbi.nlm.nih.gov/15734727/" target="_blank" rel="nofollow"> PMID: 15734727</a></p><p>Abraham et al (2006) Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease Eur.J.Pharmacol. <strong>533</strong> 215 <a href="https://pubmed.ncbi.nlm.nih.gov/16455073/" target="_blank" rel="nofollow">PMID: 16455073</a></p>
- Sequence:
- H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C50H73N15O11