Hoe 140
About this Product
- SKU:
- PN-090
- Additional Names:
- Icatibant
- CAS Number:
- 130308-48-4
- Extra Details:
- Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.
- Molecular Weight:
- 1304.5
- Purity:
- >95% by HPLC
- References:
- <p>Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. <strong>102</strong> 769 PMID: 1364851 </p><p>Perkins et al (1993) Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain<strong> 53</strong>(2) 191 https://doi.org/10.1016/0304-3959(93)90080-9. </p><p>Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. <strong>551</strong> 108 PMID: 17026984</p>
- Sequence:
- H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C59H89N19O13S