R 715
About this Product
- SKU:
- PN-070
- Additional Names:
- R 715, bradykinin B1, antagonist, hypernociception, neuropathy, pain, Ac-KRPPGFS-DB BetaNal-I-OH, Ac-KRPPGFS-DB BetaNal-I-OH, 185052-09-9, KRPPGFSXI, R715, PN-070, PN070
- CAS Number:
- 185052-09-9
- Extra Details:
- R 715 is a potent and selective bradykinin B1 receptor antagonist with a pA2 of 8.49 and no activity at B2 receptors. R 715 is metabolically stable and can reduce mechanical hypernociception in a mouse model of neuropathic pain.
- Immunogen:
- Bradykinin receptors
- Molecular Weight:
- 1140,4
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension <strong>28</strong> 833 PMID: 8901831 </p><p>Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. <strong>28</strong> 2856 PMID: 18337416 </p><p>Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. <strong>154</strong> 136 PMID: 18311190</p>
- Sequence:
- Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-DB BetaNal-Ile-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 5 mg/ml in water
- Formula:
- C57H81N13O12
