Peptide5
About this Product
- SKU:
- PN-020
- Additional Names:
- Connexin43 mimetic peptide 5|H-VDCFLSRPTEKT-OH, VDCFLSRPTEKT, 916977-43-0, connexin43 mimetic peptide 5, connexin43 (Cx43) protein, Connexin43 hemichannels, neuropathic, PN-020, PN020
- CAS Number:
- 916977-43-0
- Extra Details:
- Peptide5, also known as connexin43 mimetic peptide 5, was designed to bind to extracellular regions of the connexin43 (Cx43) protein, and is a blocker of Connexin43 hemichannels. Connexin43 hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury and Peptide 5 can reduce swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury. Peptide5 exhibits analgesic effects in models of neuropathic pain.
- Immunogen:
- Gap junction channels
- Molecular Weight:
- 1395.6
- Physical State:
- Freeze dried sold
- Purity:
- >95%
- References:
- <p>O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. <strong>15</strong> 27 PMID: 18649176 </p><p>Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. <strong>235</strong> 3033 PMID: 28725925 </p><p>Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol.<strong> 300</strong> 1 PMID: 29055716</p>
- Sequence:
- H-Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C60H98N16O20S
