Nociceptin
About this Product
- SKU:
- PN-010
- Additional Names:
- Orphanin FQ|orphanin FQ, Nociceptin, neuropeptide, nociceptin receptor, NOP, ORL-1, antianalgesic, pain, analgesic , FGGFTGARKSARKLANQ, 170713-75-4, PN-010, PN010
- CAS Number:
- 170713-75-4
- Extra Details:
- Nociceptin/orphanin FQ (N/OFQ) is a 17-amino acid neuropeptide and an endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin is derived from the prepronociceptin protein, as also are nocistatin and NocII, which inhibit N/OFQ receptor function. The name ~nociceptin' derives from the discovery that it can produce a pro-nociceptive response, and nociceptin acts as an anti-analgesic, counteracting the effect of pain-relievers. Nociceptin is widely distributed in the CNS and acts on numerous brain activities including pain sensation and fear. When administered to the spinal cord, nociceptin produces similar analgesic effects to the classical opioids.
- Immunogen:
- Nociceptin receptors
- Molecular Weight:
- 1809
- Physical State:
- Freeze dried solid
- Purity:
- %95% by HPLC
- References:
- <p>Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature <strong>377</strong> 532 PMID: 7566152</p><p>Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science <strong>270</strong> 792 PMID: 7481766</p><p> </p><p>Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS <strong>18</strong> 293 PMID: 9277133 </p><p> </p><p><br></p>
- Sequence:
- H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid and physiological buffers. Soluble in DMSO
- Formula:
- C79H129N27O22
