Multi-Leu peptide
Product Sizes
1 mg
£135.00
PI-290-1MG
About this Product
- SKU:
- PI-290
- Additional Names:
- ML-peptide, Multi-Leucine (ML)-peptide|Multi-leu peptide, PI-290, PI290, Ac-LLLLRVKR-NH2, ML-peptide, Multi-Leucine (ML)-peptide, ml peptide
- Extra Details:
- Multi-Leu peptide is a peptide identified from a partial combinatorial library that is selective for the proprotein convertase PACE4, notably being 20 fold selective over furin, a closely related enzyme with similar structural characteristics. Proprotein convertases play an important role in protein precursor activation through processing at paired basic residues and PACE4 specifically has an important role in prostate cancer. Consistent with inhibition of PACE4, Multi-Leu peptide significantly reduces the proliferation of DU145 and LNCaP prostate cancer derived cell lines and induces G0/G1 cell cycle arrest.
- Immunogen:
- Serine proteases
- Molecular Weight:
- 1050.74
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Levesque et al (2012) The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J Med Chem. <strong>55</strong>(23) 10501 <a href="https://pubmed.ncbi.nlm.nih.gov/23126600/" target="_blank">PMID: 23126600</a></p><p>Kwiatkowska et al (2019) Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug. Sci Rep. <strong>9</strong> 2118 <a href="https://pubmed.ncbi.nlm.nih.gov/30765725/" target="_blank">PMID: 30765725</a></p>
- Sequence:
- Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C49H94N16O9
