Compstatin
Product Sizes
Compstatin
£176.00
PI-270
About this Product
- SKU:
- PI-270
- CAS Number:
- 206645-99-0
- Extra Details:
Compstatin, a cyclic tridecapeptide, discovered from a phage-display library, is a highly potent and selective complement component 3 (C3) inhibitor, binding to C3, C3b, and C3c, but not to C3d. Compstatin binds to C3 in a reversible manner and inhibits proteolytic cleavage by C3 convertase to the proteins C3a and C3b and consequent activation of classical and alternative complement pathways. Compstatin accordingly acts as a complement inhibitor and prolongs graft survival and reduces hyperacute rejection of pig kidneys perfused with human blood, and inhibits in vivo heparin/protamine induced complement activation in primates.
- Molecular Weight:
- 1550.77
- Purity:
- >95% by HPLC
- References:
- <p>Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. <strong>157</strong>(2) 884Â <a href="https://pubmed.ncbi.nlm.nih.gov/8752942/" target="_blank">PMID: 8752942</a></p><p>Ricklin and Lambris (2008) Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol.<strong> 632</strong> 273Â <a href="https://pubmed.ncbi.nlm.nih.gov/19025129/" target="_blank">PMID: 19025129</a></p><p>Mastellos et al (2015) Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest. <strong>45</strong>(4) 423Â <a href="https://pubmed.ncbi.nlm.nih.gov/25678219/" target="_blank">PMID: 25678219</a>
- Sequence:
- H-Ile-*Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-*Cys-Thr-NH2 (disulphide bridge between cysteines 2 and 12)
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C66H99N23O17S2