Z-VAD-FMK
About this Product
- SKU:
- PI-250
- Additional Names:
- Z-VAD-FMK, Z-Val-Ala-Asp(OMe)-FMK, cell-permeable, caspase inhibitor, 187389-52-2, PI-250, PI250|Z-Val-Ala-Asp(OMe)-FMK
- CAS Number:
- 187389-52-2
- Extra Details:
- Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 - 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings.
- Immunogen:
- Caspases
- Molecular Weight:
- 467.49
- Physical State:
- White lyophilised solid
- Purity:
- >98% by TLC
- References:
- <p>Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. <strong>315</strong> 21 PMID: 8670109 </p><p>Ilangovan et al (2003) Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. <strong>278</strong>(33) 30993 doi:10.1074/jbc.M303763200 </p><p>Simmons et al (2009) Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect. Dis. Obstet. Gynecol. 2009 749432. doi:10.1155/2009/749432</p>
- Sequence:
- Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, dark and frozen
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 10 mg/mL in DMSO
- Formula:
- C22H30FN3O7
