WP 1130
Product Sizes
10 mg
£118.00
PI-240-10MG
About this Product
- SKU:
- PI-240
- Additional Names:
- Degrasyn|WP 1130, degrasyn, deubiquitinase, DUB, USP9x, USP5, USP14, UCH37, 856243-80-6, PI-240, PI240
- CAS Number:
- 856243-80-6
- Extra Details:
- WP 1130, also known as degrasyn, is a cell-permeable deubiquitinase (DUB) inhibitor, able to directly inhibit the DUB activity of USP9x, USP5, USP14, and UCH37. WP 1130 has been shown to downregulate both wild-type and mutant Bcr/Abl without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. WP 1130 can cause marked anti-proliferative activity and morphological changes in NCH644 and NCH421K glioma stem-like cells.
- Immunogen:
- Deubiquitinating enzymes
- Molecular Weight:
- 384.3
- Physical State:
- Solid
- Purity:
- >98%
- References:
- <p>Bartholomeusz et al (2007) Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. <strong>109</strong>(8) 3470 doi:10.1182/blood-2006-02-005579 </p><p>Bartholomeusz et al (2007) Degrasyn activates proteasomal-dependent degradation of c-Myc. Cancer Res. <strong>67</strong>(8) 3912 doi:10.1158/0008-5472.CAN-06-4464 </p><p>Kapuria et al (2010) Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res. <strong>70</strong>(22) 9265 doi:10.1158/0008-5472.CAN-10-1530</p>
- Sequence:
- (2E)<-3-<(6-<bromo-<2-<pyridinyl)<-<2-<cyano-<N-<[1S-<phenylbutyl]<-2-<propenamide
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO and ethanol
- Formula:
- C19H18BrN3O
