Vildagliptin
Product Sizes
10 mg
£71.00
PI-230-10MG
About this Product
- SKU:
- PI-230
- Additional Names:
- 274901-16-5, Vildagliptin, LAF237, dipeptidyl peptidase IV, DPP-IV, antihyperglycemic, type 2 diabetes, PI-230, PI230|LAF237
- CAS Number:
- 274901-16-5
- Extra Details:
- Vildagliptin, also known as LAF237, is a potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin inhibits the inactivation of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) by DPP-IV, allowing GLP-1 and GIP to potentiate the secretion of insulin and suppress glucagon release in the pancreas. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity in type 2 diabetes.
- Immunogen:
- Dipeptidyl peptidase IV
- Molecular Weight:
- 303.4
- Physical State:
- Solid
- Purity:
- 0.98
- References:
- <p>Villhauer et al (2003) 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med. Chem. <strong>46</strong>(13) 2774 doi:10.1021/jm030091l </p><p>AhreÌn et al (2004) Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes. J. Clin. Endocrinol. Metab. <strong>89</strong>(5) 2078 https://doi.org/10.1210/jc.2003-031907 </p><p>Wu et al (2015) Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism <strong>64</strong>(2) 226 doi:10.1016/j.metabol.2014.08.006</p>
- Sequence:
- 1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in water
- Formula:
- C17H25N3O2
