TPCK
Product Sizes
500 mg
£106.00
PI-220-500MG
About this Product
- SKU:
- PI-220
- Additional Names:
- TPCK, chymotrypsin-like serine protease inhibitor, apoptosis, 402-71-1, PI-220, PI220
- CAS Number:
- 402-71-1
- Extra Details:
- TPCK is an irreversible chymotrypsin-like serine protease inhibitor, acting as an alkylating agent that interferes with translation. TPCK is useful for inhibiting chymotrypsin activity in trypsin preparations. TPCK also inhibits apoptosis in thymocytes and blocks the induction of nitric oxide synthase by I³-interferon and lipopolysaccharides.
- Immunogen:
- Serine proteases
- Molecular Weight:
- 351.85
- Physical State:
- Solid
- Purity:
- %98% by TLC
- References:
- <p>Fearnhead et al (1995) A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli, FEBS Lett. <strong>357</strong> 242 doi: 10.1016/0014-5793(94)01367-</p><p>A Griscavage et al (1996) Inhibitors of the Proteasome Pathway Interfere with Induction of Nitric Oxide Synthase in Macrophages by Blocking Activation of Transcription Factor NF-kappa. Proc. Natl. Acad. Sci. USA <strong>93</strong>(8) 1996, pp. 3308 www.jstor.org/stable/38955</p>
- Sequence:
- N-p-Tosyl-L-phenylalanine chloromethyl ketone
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 500 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO
- Formula:
- C17H18ClNO3S
