TLCK
Product Sizes
50 mg
£83.00
PI-210-50MG
About this Product
- SKU:
- PI-210
- Additional Names:
- 4272-74-6, TLCK, serine protease, lipopolysaccharide, cyclooxygenase-2 , COX-2, caspase, PI-210, PI210
- CAS Number:
- 4272-74-6
- Extra Details:
- TLCK is a trypsin-like serine protease inhibitor which can block lipopolysaccharide (LPS)- or cytokine-induced activation of nuclear factor K Kappa B (NF- K Kappa B), which, in turn blocks the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) transcription. TLCK blocks activation of pp70s6k by all mitogens and prevents apoptosis in cell lines by inhibiting caspase processing. TLCK has been used in chymotrypsin purification to prevent binding of trypsins to the affinity support, as a protease inhibitor in tissue and cell homogenization and as a trypsin inhibitor to determine specific protease activity levels.
- Immunogen:
- Serine proteases,Other proteases
- Molecular Weight:
- 369.31
- Physical State:
- Off white powder
- Purity:
- %96% (TLC)
- References:
- <p>Kwon et al (1998) Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes <strong>47</strong>(4) 583 doi:10.2337/diabetes.47.4.583 </p><p>Ménoret (2004) Purification of recombinant and endogenous HSP70s. Methods <strong>32</strong>(1) 7 doi:10.1016/s1046-2023(03)00180-4</p>
- Sequence:
- (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 50 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in water
- Formula:
- C14H21ClN2O3S · HCl
