Sivelestat
About this Product
- SKU:
- PI-180
- Additional Names:
- 127373-66-4, Sivelestat, ONO 5046, human neutrophil elastase, leukocyte elastase, neuropathic pain, PI-180, PI180|ONO 5046
- CAS Number:
- 127373-66-4
- Extra Details:
- Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044 uM. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100uM. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain.
- Immunogen:
- Serine proteases
- Molecular Weight:
- 434.46
- Physical State:
- Solid
- Purity:
- >95%
- References:
- <p>Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Comm. <strong>177</strong>(2) 814 https://doi.org/10.1016/0006-291X(91)91862-7 </p><p>Weyer and Stucky (2015) Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nat. Med.<strong> 21</strong> 429 https://doi.org/10.1038/nm.3861</p>
- Sequence:
- Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, dark and frozen
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO
- Formula:
- C20H22N2O7S · xNa+ · yH2O
