SB 3CT
About this Product
- SKU:
- PI-170
- Additional Names:
- 292605-14-2, SB 3CT, MMP2, MMP9, neuroprotective, PI-170 PI170
- CAS Number:
- 292605-14-2
- Extra Details:
- SB 3CT is a potent, competitive and non-selective MMP2 inhibitor with a Ki of 28 nM which also inhibits MMP9 to a lesser extent (Ki = 400 nM). SB 3CT is active in vivo, neuroprotective and blood-brain barrier permeable.
- Immunogen:
- Matrix metalloproteases
- Molecular Weight:
- 306.4
- Physical State:
- Solid
- Purity:
- >98% by tlc
- References:
- <p>Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. <strong>18</strong> 17125 PMID: 11278946</p><p>Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci.<strong> 25</strong> 6401 PMID: 16000631 </p><p>Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. <strong>3</strong> 730 PMID: 23077716</p>
- Sequence:
- 2-[[(4-phenoxyphenyl)sulfonyl]methyl]thiirane
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO and ethanol
- Formula:
- C15H14O3S2
