PR 619
About this Product
- SKU:
- PI-150
- Additional Names:
- PR 619, deubiquitinylating enzymes, DUBs, cancer, 2645-32-1, PR619, PI-150, PI150
- CAS Number:
- 2645-32-1
- Extra Details:
- PR 619 is a broad spectrum, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with an EC50 of 1-20 uM in a cell-free assay and only limited activity against other proteases. PR 619 induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. PR 619 is cytotoxic in HEK293T and colorectal cancer cells and stabilizes microtubule networks in oligodendroglial cells.
- Immunogen:
- Deubiquitinating enzymes
- Molecular Weight:
- 223.28
- Physical State:
- Solid
- Purity:
- >98%
- References:
- <p>Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. <strong>18</strong> 1401 PMID: 22118674 </p><p>Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta <strong>1823</strong> 2057 PMID: 22565157</p>
- Sequence:
- 2,6-Diamino-3,5-dithiocyanopyridine
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble to 10 mM in DMSO
- Formula:
- C7H5N5S2
