Phosphoramidon disodium
About this Product
- SKU:
- PI-130
- Additional Names:
- 119942-99-3, Phosphoramidon, metallo-endopeptidase, thermolysin, enkephalinase, neprilysin, amyloid beta (AB Beta) uptake, PI-130, PI130
- CAS Number:
- 119942-99-3
- Extra Details:
- Phosphoramidon is a metalloendopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases and also strongly inhibits mammalian enkephalinase but does not inhibit trypsin, papain, chymotrypsin or pepsin. Phosphoramidon has been used as a neprilysin (NEP) inhibitor to study amyloid beta (AB Beta) uptake and degradation.
- Immunogen:
- Matrix metalloproteases,Other proteases
- Molecular Weight:
- 587.47
- Physical State:
- Off white powder
- Purity:
- %97% (HPLC)
- References:
- <p>Bao et al (2016) Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia. Protein Cell <strong>7</strong>(6) 417 doi:10.1007/s13238-016-0269-2 </p><p>Goblirsch et al (2018) Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24. Acta. Crystallogr. D Struct. Biol. <strong>74</strong>(Pt 8) 739 doi:10.1107/S2059798318003431 </p><p>Li et al (2018) SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes. Neural Regen. Res. <strong>13</strong>(11) 2005 doi:10.4103/1673-5374.239449</p>
- Sequence:
- N-(A Alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- 50 mg per ml in water
- Formula:
- C23H32N3O10P•2Na
