PD 150606
Product Sizes
10 mg
£118.00
PI-110-10MG
About this Product
- SKU:
- PI-110
- Additional Names:
- 179528-45-1, PD 150606, calpain inhibitor , PI-110
- CAS Number:
- 179528-45-1
- Extra Details:
- PD 150606 is a cell-permeable non-peptide calpain inhibitor with Ki values for I½ and m-calpains of 0.21 and 0.37 uM. PD 150606 targets the calcium binding sites of calpain and possesses very high selectivity for calpains relative to other proteases, acting as a non-competitive inhibitor with regard to the substrate.
- Immunogen:
- Calcium sensitive proteases
- Molecular Weight:
- 306.12
- Physical State:
- Solid
- Purity:
- %95% (HPLC)
- References:
- <p>Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. <strong>93</strong> 6687 PMID: 8692879 </p><p>Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. <strong>283</strong> 1177 PMID: 9399991 </p><p>Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. <strong>178</strong> 311 PMID: 9989777</p>
- Sequence:
- Z-3-4-Iodophenyl-2-mercapto-2-propenoic acid
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO and ethanol
- Formula:
- C9H7IO2S
