P5091
Product Sizes
10 mg
£106.00
PI-100-10MG
About this Product
- SKU:
- PI-100
- Additional Names:
- 882257-11-6, P5091, ubiquitin-specific protease 7, USP7, apoptosis, antiangiogenic, PI-100, PI100
- CAS Number:
- 882257-11-6
- Extra Details:
- P5091 is a selective and inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 4.2 uM. P5091 displays little or no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases but does have some activity at USP47. P5091 induces elevated p53 and apoptosis in cancer cell lines and possesses antiangiogenic activity in vivo.
- Immunogen:
- Deubiquitinating enzymes
- Molecular Weight:
- 348.22
- Physical State:
- Solid
- Purity:
- %98% (HPLC)
- References:
- <p>Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. <strong>3</strong> 789 </p><p>Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell <strong>22</strong> 345 PMID: 22975377</p>
- Sequence:
- 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble to 10 mM in DMSO
- Formula:
- C12H7Cl2NO3S2
