P32/98
Product Sizes
10 mg
£118.00
PI-090-10MG
About this Product
- SKU:
- PI-090
- Additional Names:
- 136259-20-6, P32/98, isoleucyl thiazolidide, dipeptidyl peptidase IV, DPP IV, PI-090, PI090|Isoleucyl thiazolidide
- CAS Number:
- 136259-20-6
- Extra Details:
- P32/98, also known as isoleucyl thiazolidide, is a potent and selective cell permeable inhibitor of dipeptidyl peptidase IV (DPP IV) with a Ki of 130 nM. P32/98 inhibition of DPP IV prevents degradation of both gastric inhibitory peptide (GIP) and Glucagon-like peptide-1, enhancing insulin secretion. P32/98 improves glucose tolerance, insulin sensitivity and beta-cell glucose responsiveness in diabetic fatty rats following oral administration.
- Immunogen:
- Dipeptidyl peptidase IV
- Molecular Weight:
- 260.35
- Physical State:
- Solid
- Purity:
- 0.98
- References:
- <p>Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes <strong>47</strong> 1253 PMID: 9703325 </p><p>Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral Ins sensitivity in the VDF Zucker rat. Diabetes <strong>51</strong> 2677 PMID: 12196458 </p><p>Wagner et al (2016) Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation. Neuropeptides. <strong>57</strong> 21 doi:10.1016/j.npep.2016.02.007</p>
- Sequence:
- (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO or in water (up to 20 mg/ml).
- Formula:
- C9H18N2OS 1/2C4H4O4
