NSC 405020
Product Sizes
10 mg
£106.00
PI-070-10MG
About this Product
- SKU:
- PI-070
- Additional Names:
- 7497-07-6, NSC 405020, matrix metalloproteinase, membrane type-1 matrix metalloproteinase, MT1-MMP, MMP 14, tumour cell invasion, PI-070, PI070
- CAS Number:
- 06/07/7497
- Extra Details:
- NSC 405020 is a matrix metalloproteinase inhibitor that targets the hemopexin domain (PEX) of membrane type-1 matrix metalloproteinase (MT1-MMP, also known as MMP 14). The hemopexin domain is distinct from and additional to the catalytic domain and inhibition with NSC 405020 affects PEX and the ability of MT1-MMP to function properly to degrade COL-I to support tumour cell invasion. Intratumoral injections of NSC 405020 significantly repress tumour growth.
- Immunogen:
- Matrix metalloproteases
- Molecular Weight:
- 260.16
- Physical State:
- Solid
- Purity:
- >98% by PHLC
- References:
- <p>Remade et al (2012) Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth. Cancer Res. 72(9) 2339 DOI: 10.1158/0008-5472.CAN-11-4149 </p><p>Mastenbroek et al (2015) Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arteriosclerosis, Thrombosis, and Vascular Biology. Arterioscl. Thromb. Vasc. Biol. 35 2554 https://doi.org/10.1161/ATVBAHA.115.306153</p>
- Sequence:
- 3,4-Dichloro-N-(1-methylbutyl)benzamide
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, dark and frozen
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO
- Formula:
- C12H15Cl2NO
