Nafamostat mesylate
Product Sizes
10 mg
£95.00
PI-040-10MG
About this Product
- SKU:
- PI-040
- Additional Names:
- 82956-11-4, Nafamostat, serine protease inhibitor, Lys/Arg specific serine proteinases, tryptase, antiviral, PI-040, PI040
- CAS Number:
- 82956-11-4
- Extra Details:
- Nafamostat mesylate is a serine protease inhibitor. It inhibits a large number of Lys/Arg specific serine proteinases, and is also a tryptase inhibitor. In vivo nafamostat is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Nafamostat also has some antiviral and anti-cancer properties and has been identified as a potential treatment for COVID-19.
- Immunogen:
- Serine proteases,Other proteases
- Molecular Weight:
- 539.59
- Physical State:
- Solid
- Purity:
- >98%
- References:
- <p>Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br. J. Pharmacol. <strong>138</strong> 959 PMID: 12642398 </p><p>Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J. Allergy Clin. Immunol. <strong>118</strong> 105 PMID: 16815145 </p><p>Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. <strong>30</strong>(3) 269 doi:10.1038/s41422-020-0282-0</p>
- Sequence:
- 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble to 100 mM in water
- Formula:
- C19H17N5O2.2CH4O3S
