MG 132
About this Product
- SKU:
- PI-030
- Additional Names:
- MG 132, Z-Leu-Leu-Leu-CHO, Z-LLL-al, 133407-82-6, chymotrypsin-like activity, 20S proteasome, calpain, 133407-82-6, PI-030, PI030|Z-LLL-al, Z-Leu-Leu-Leu-CHO
- CAS Number:
- 133407-82-6
- Extra Details:
- MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-A Alpha-induced NF- K Kappa B activation and I K Kappa BA Alpha degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.
- Immunogen:
- Proteasome
- Molecular Weight:
- 475.63
- Physical State:
- Freeze dried solid
- Purity:
- >98%
- References:
- <p>Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. <strong>21</strong> 3941 PMID: 11911275 </p><p>Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. <strong>119</strong> 572 PMID: 8830056 </p><p>Ma et al (2020) Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. <strong>30</strong> 678 https://doi.org/10.1038/s41422-020-0356-z</p>
- Sequence:
- Z-Leu-Leu-Leu-CHO
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL)
- Formula:
- C26H41N3O5
