MDL 28170
Product Sizes
10 mg
£95.00
PI-020-10MG
About this Product
- SKU:
- PI-020
- Additional Names:
- Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal,|MDL 28170, calpain, cathepsin B, neuroprotective, 88191-84-8, Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, PI-020, PI020
- CAS Number:
- 88191-84-8
- Extra Details:
- MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.
- Immunogen:
- Calcium sensitive proteases
- Molecular Weight:
- 382.45
- Physical State:
- Freeze dried solid
- Purity:
- %95% (HPLC)
- References:
- <p>Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. <strong>247</strong> 17 PMID: 9637399 </p><p>Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS <strong>16 </strong>150 PMID: 1877091 </p><p>Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma <strong>24</strong> 960 PMID: 17600513</p>
- Sequence:
- N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C22H26N2O4
