LDN 57444
Product Sizes
10 mg
£106.00
PI-001-10MG
About this Product
- SKU:
- PI-001
- Additional Names:
- LDN 57444, ubiquitin C-terminal hydrolase-L1, UCH-L1, ubiquitin proteasome, 668467-91-2, PI-001, PI001
- CAS Number:
- 668467-91-2
- Extra Details:
- LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity with a Ki of 0.4 uM. UCH-L1 is a deubiquitinating enzyme that is abundantly expressed in the brain, and its activity is required for normal synaptic function. Inhibition by LDN 57444 causes cell death through the apoptosis pathway, increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity.
- Immunogen:
- Deubiquitinating enzymes
- Molecular Weight:
- 397.64
- Physical State:
- Freeze dried solid
- Purity:
- %98% by HPLC
- References:
- <p>Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. <strong>10</strong> 837 PMID: 14522054</p><p> Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. <strong>318</strong> 109 PMID: 18622688 </p><p>Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci.<strong> 29</strong> 7857 PMID: 19535597</p>
- Sequence:
- 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble to 50 mM in DMSO
- Formula:
- C17H11Cl3N2O3
