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Proteins and Peptides

PACAP 38

Product Sizes
1 mg
£236.00
PA-020-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
PA-020
Additional Names:
PACAP 38, PACAP38, HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH, HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK, 124123-15-5, PA-020, PA020|Pituitary Adenylate Cyclase-Activating Polypeptide 1-38, PACAP 1-38
CAS Number:
124123-15-5
Extra Details:
PACAP 38, or Pituitary adenylate cyclase activating polypeptide-38, is a widely distributed endogenous neuropeptide located in both sensory and parasympathetic perivascular nerve fibes. PACAP 38 acts primarily as a PAC1 agonist and is involved in neuroprotection, neurodevelopment, nociception and inflammation. PACAP 38 is a potent inducer of migraine like attacks in migraineurs and headache in non migraineurs.
Immunogen:
PACAP receptors
Molecular Weight:
4534.32
Physical State:
Freeze dried solid
Purity:
95%
References:
<p>Lazarovici et al (1998) The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor Mol.Pharmacol. <strong>54</strong> 547 PMID: 9730914</p><p>Rubio-Beltrán et al (2018) PACAP38 and PAC1 receptor blockade: a new target for headache?. J Headache Pain <strong>19</strong> 64 https://doi.org/10.1186/s10194-018-0893-8<br></p><p>Pedersen et al (2019) PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor.  Front. Cellular Neuroscience <strong>13</strong> 114 https://www.frontiersin.org/article/10.3389/fncel.2019.00114 </p>
Sequence:
H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble to 0.90 mg/ml in water
Formula:
C203H331N63053S