Orexin A (human, rat, mouse)
Product Sizes
0.5 mg
£189.00
OX-050-0.5MG
About this Product
- SKU:
- OX-050
- Additional Names:
- Hypocretin 1|Orexin A (human, rat, mouse), OX-050, XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2, 205640-90-0, hypocretin 1
- CAS Number:
- 205640-90-0
- Extra Details:
- Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.
- Immunogen:
- Orexin receptors
- Molecular Weight:
- 3561.12
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 <a href="https://pubmed.ncbi.nlm.nih.gov/9491897/" target="_blank" rel="nofollow">PMID: 9491897</a></p><p>Deadwyler et al (2007) Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. <strong>27</strong>(52) 14239 <a href="https://pubmed.ncbi.nlm.nih.gov/18160631/" target="_blank" rel="nofollow">PMID: 18160631</a></p><p>Sakurai (2014) The role of orexin in motivated behaviours. Nat Rev Neurosci.<strong> 15</strong>(11) 719 <a href="https://pubmed.ncbi.nlm.nih.gov/25301357/" target="_blank" rel="nofollow">PMID: 25301357</a></p><p><a href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1697" target="_blank" rel="nofollow">Guide to Pharmacology - Orexin A</a><br></p>
- Sequence:
- Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 0.5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C152H243N47O44S4
