[Ala11, D-Leu15]-Orexin B
About this Product
- SKU:
- OX-040
- Additional Names:
- [Ala(11), D-Leu(15)]orexin-B, [Ala11, d-Leu15]-OrxB, Selective OX2R agonist|[Ala11, D-Leu15]-Orexin B, 532932-99-3, RSGPPGLQGRAQRLLQASGNHAAGILTM, RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2, [Ala(11), D-Leu(15)]orexin-B, OX-040, OX040
- CAS Number:
- 532932-99-3
- Extra Details:
- [Ala11, D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models.
- Immunogen:
- Orexin receptors
- Molecular Weight:
- 2857.28
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett.<strong> 13</strong> 111 PMID: 12467628</p><p>Borgland et al (2008), Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. European J. Neuroscience <strong>28</strong> 1545 https://doi.org/10.1111/j.1460-9568.2008.06397.x</p><p>Staton et al (2018) Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression, Neuropharmacology <strong>143</strong> 79 https://doi.org/10.1016/j.neuropharm.2018.09.016<br></p>
- Sequence:
- H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 0.30 mg/ml in water
- Formula:
- C189H284N54O56S
