Orexin B (human)
About this Product
- SKU:
- OX-020
- Additional Names:
- Orexin B (human), 205640-91-1, RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2, RSGPPGLQGRLQRLLQASGNHAAGILTM, OX-020, OX020
- CAS Number:
- 205640-91-1
- Extra Details:
- Orexin B (human) is an endogenous agonist peptide at orexin receptors with some selectivity for OX2 (with Ki values of 420 and 36 nM for OX1 and OX2 receptors respectively). Orexin B (human) stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin B (human) is neuroprotective for dopaminergic neurons in animal models.
- Immunogen:
- Orexin receptors
- Molecular Weight:
- 2899.37
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Smart (1999) Orexins: a new family of neuropeptides. Br J Anaesth.<strong> 83</strong>(5) 695 doi: 10.1093/bja/83.5.695</p><p>Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol Pharmacol. <strong>87</strong>(3) 525 doi: 10.1124/mol.114.095703</p><p>Shingo and Sakurai (2020) Evolution of Orexin Neuropeptide System: Structure and Function. Frontiers in Neuroscience <strong>14</strong> 691 www.frontiersin.org/article/10.3389/fnins.2020.00691 <br></p><p><br></p>
- Sequence:
- H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C123H212N44O35S
