SHBG141-161
About this Product
- SKU:
- OR-030
- Additional Names:
- OR-030, OR030, SHBG141-161, IALGGLLFPASNLRLPLVPAL,|SHBG(141-161) domain peptide, SHBG(141-161)
- Extra Details:
- SHBG141-161 is a peptide corresponding to amino acids 141-161 of sex hormone binding globulin (SHBG), the loop region of SHBG connecting B Beta-strands 11 and 12. SHBG141-161 is an agonist of the class C orphan G protein coupled receptor GPRC6A, a major regulator of energy metabolism and male fertility, and SHBG141-161 competes for binding to it with its endogenous ligand undercarboxylated osteocalcin (ucOCN). In vitro, SHBG141-161 stimulates insulin secretion from B Beta-cells and also the production and release of testosterone from Leydig and Langerhans B Beta-cells cell lines.
- Immunogen:
- Orphan 7-TM receptors
- Molecular Weight:
- 2145.66
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- De Toni et al (2019) SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines. Sci Rep. <strong>9</strong>(1) 19432 <a href="https://pubmed.ncbi.nlm.nih.gov/31857654/" target="_blank">PMID: 31857654</a>
- Sequence:
- H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C103H173N25O24
