Prosaptide TX14(A)
About this Product
- SKU:
- OR-010
- Additional Names:
- 16-29-Saposin C, TX14(A)|Prosaptide TX14(A), 196391-82-9, TaLIDNNATEEILY, 16-29-Saposin C, OR-010, OR010
- CAS Number:
- 196391-82-9
- Extra Details:
- Prosaptide TX14(A) is derived from the active region of saposin C, itself derived from proteolytic processing of prosaposin, a 517-amino acid residue protein and neurotropic factor. Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1 with EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37. Prosaptide TX14(A) can protect primary astrocytes against oxidative stress, prolongs cell survival in both Schwann cells and oligodendrocytes and has anti-allodynic properties in a rat model of gp120-induced tactile allodynia.
- Immunogen:
- Orphan 7-TM receptors
- Molecular Weight:
- 1579.72
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci U S A. <strong>94</strong>(9) 4778 <a href="https://pubmed.ncbi.nlm.nih.gov/9114068/" target="_blank" rel="nofollow">PMID: 9114068</a></p><p>Jolivalt et al (2008) Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. <strong>12</strong>(1) 76 <a href="https://pubmed.ncbi.nlm.nih.gov/17466547/" target="_blank" rel="nofollow">PMID: 17466547</a></p><p>Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. <strong>110</strong> 9529 <a href="https://pubmed.ncbi.nlm.nih.gov/23690594/" target="_blank">PMID: 23690594</a></p>
- Sequence:
- H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C69H110N16O26
