Pep2-8
About this Product
- SKU:
- OP-020
- Additional Names:
- Pep 2-8, Ac-TVFTSWEEYLDWV-NH2, 1541011-97-5, Pep2-8
- CAS Number:
- 1541011-97-5
- Extra Details:
- Pep2-8 is a peptide from a phage library that was identified as the smallest proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitor) with a clearly defined mechanism of inhibition. Pep2-8 binds to PCSK9 with a KD of 0.7 um but has no affinity for other proprotein convertases. Pep2-8 restores low density lipoprotein (LDL) receptor function and LDL uptake in PCSK9-treated HepG2 cells.
- Immunogen:
- Other proteases
- Molecular Weight:
- 1715.88
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem.<strong> 289</strong> 942 <a href="https://pubmed.ncbi.nlm.nih.gov/24225950/" target="_blank">PMID: 24225950</a>
- Sequence:
- Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in PBS
- Formula:
- C83H110N16O24
