[Leu31,Pro34]-Neuropeptide Y (human, rat)
About this Product
- SKU:
- NY-020
- Additional Names:
- [Leu31,Pro34]-Neuropeptide Y (human, rat), [Leu31,Pro34]-NPY (human), 132699-73-1, YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY, YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2|[Leu31,Pro34]-NPY (human)
- CAS Number:
- 132699-73-1
- Extra Details:
- [Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist with a Ki of 0.39 nM, and also some affinity for Y4 and Y5 receptors. [Leu31,Pro34]-NPY microinjected into the periaqueductal gray produces both analgesic and anxiolytic effects in rats, and intrathecal administration of [Leu31,Pro34]-Neuropeptide Y (human, rat) can attenuate itch behaviour in mice.
- Immunogen:
- Neuropeptide Y receptors
- Molecular Weight:
- 4241
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. <strong>87</strong> 182 PMID: 2153286</p><p>Vázquez-León (2017) Analgesic and anxiolytic effects of [Leu31,Pro34]-neuropeptide Y microinjected into the periaqueductal gray in rats, Neuropeptides <strong>66 </strong>81 https://doi.org/10.1016/j.npep.2017.10.001</p><p>Gao et al (2018) The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch. J. Investigative Dermatology <strong>138</strong>(11) 2405 https://doi.org/10.1016/j.jid.2018.05.008<br></p>
- Sequence:
- H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C189H284N54O56S
