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Proteins and Peptides

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide

Product Sizes
1 mg
£224.00
NY-010-1MG
Academic Pricing
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About this Product
SKU:
NY-010
Additional Names:
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]hPP|GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2, GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY, 313988-89-5, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]hPP, GPSQPTYPGDNATPEQMARYYSALRRYINMABRQRY-NH2
CAS Number:
313988-89-5
Extra Details:
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of 0.1 - 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide stimulates food intake in vivo.
Immunogen:
Neuropeptide Y receptors
Molecular Weight:
4207.67
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem.<strong> 275</strong> 36043 PMID: 10944518</p><p>Quarta et al (2011) Central administration of NPY or an NPY-Y5 selective agonist increase in vivo extracellular monoamine levels in mesocorticolimbic projecting areas. Neuropharmacology <strong>60</strong>(2-3) 328 doi: 10.1016/j.neuropharm.2010.09.016</p><p>Medeiros and Jackson (2013) Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. Peptides <strong>48</strong> 106 doi: 10.1016/j.peptides.2013.07.029<br></p>
Sequence:
H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble to 1 mg/ml in water
Formula:
C183H281N57O54S2