MDANP
Product Sizes
1 mg
£177.00
NR-220-1MG
About this Product
- SKU:
- NR-220
- Additional Names:
- MDANP, NR-220, NR220, NR 220, Milk-derived anti-NEC peptide, SKSKKFRRPDIQYPDATDED|Milk-derived anti-NEC peptide
- Extra Details:
- MDANP (Milk-derived anti-NEC peptide) is a peptide identified from human milk. Bioactive peptides are an important component of human milk and they exhibit a variety of functions such as anti-infection, immune regulation, and growth promotion. Endoplasmic reticulum (ER) stress plays a critical role in necrotizing enterocolitis (NEC) pathogenesis through the PERK-eIF2E'-QRICH1 axis, and in an effort to identify agents in milk which can ameliorate it, MDANP is able to improve intestinal cell apoptosis and has a protective effect in mouse models. That reduction of ER stress by MDANP acts through the PERK-eIF2 A Alpha-QRICH1 pathway is shown by MDANP reducing the levels of PERK, p-eIF2, and QRICH1 proteins. MDANP both decreases the severity of NEC in neonatal mouse and ameliorates intestinal injury and reduces apoptosis.
- Immunogen:
- Nuclear receptor modulators,Kinases
- Molecular Weight:
- 2395.18
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Ser-Lys-Ser-Lys-Lys-Phe-Arg-Arg-Pro-Asp-Ile-Gln-Tyr-Pro-Asp-Ala-Thr-Asp-Glu-Asp-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
