S9pep
About this Product
- SKU:
- NR-180
- Additional Names:
- S9pep, NR-180, SOX9(208-229), ADSPHSSSGMSEVHSPGEHSG,|SOX9(208-229)
- Extra Details:
- S9pep is a short sequence of the transcription factor SOX-9, located at the hinge between the high mobility group (HMG) - DNA-binding domain and the SOX-E central conserved domain, that can mimic SOX9 tumour suppressive properties. Like full length SOX9, S9pep inhibits Wnt/B Beta-catenin signaling and the expression of c-Myc, its oncogenic target gene, by relocating B Beta-catenin from the chromatin to the cytosol. S9pep disrupts colorectal cancer cell morphology, reduces the growth of colorectal cancer cells and stem cells, and inhibits tumour development in vivo.
- Immunogen:
- Nuclear receptor modulators
- Molecular Weight:
- 2079.1
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Blache et al (2019) A Short SOX9 Peptide Mimics SOX9 Tumor Suppressor Activity and Is Sufficient to Inhibit Colon Cancer Cell Growth. Mol Cancer Ther. 2019 <strong>18</strong>(8) 1386 <a href="https://pubmed.ncbi.nlm.nih.gov/31092563/" target="_blank">PMID: 31092563</a>
- Sequence:
- H-Ala-Asp-Ser-Pro-His-Ser-Ser-Ser-Gly-Met-Ser-Glu-Val-His-Ser-Pro-Gly-Glu-His-Ser-Gly-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C82H123N27O35S
