Bombesin
About this Product
- SKU:
- NR-150
- CAS Number:
- 31362-50-2
- Extra Details:
- Bombesin is a 14 amino acid endogenous mammalian neurotransmitter which activates three different G-protein-coupled receptors, bombesin receptor (BBR) 1, -2, and -3. Bombesin exhibits many biological effects including hormone release, stimulation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. Bombesin also activates these receptors in the brain and together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour. Bombesin is also a tumour marker for small cell lung carcinoma, gastric cancer, pancreatic cancer, and neuroblastoma.
- Molecular Weight:
- 1619.9
- Purity:
- >95% by HPLC
- References:
- <p>McCoy and Avery (1990) Bombesin: potential integrative peptide for feeding and satiety. Peptides <strong>11</strong> 595 <a href="https://pubmed.ncbi.nlm.nih.gov/2199952/" target="_blank" rel="nofollow">PMID: 2199952</a></p><p>Battey and Wada (1991) Two distinct subtypes for mammalian bombesin-like peptides. TiNS <strong>14</strong> 524 <a href="https://pubmed.ncbi.nlm.nih.gov/1726343/" target="_blank" rel="nofollow">PMID: 1726343</a></p><p>Zhang et al (2012) Evolution of Bombesin Conjugates for Targeted PET Imaging of Tumors. PLoS ONE <strong>7</strong>(9) e44046 <a href="https://pubmed.ncbi.nlm.nih.gov/23024746/" target="_blank" rel="nofollow">PMID: 23024746</a></p>
- Sequence:
- pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dark, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C71H110N24O18S