Substance P
About this Product
- SKU:
- NR-140
- Additional Names:
- Neurokinin-1|Substance P, neurokinin-1, neuropeptide, neurokinin-1 receptor, NK1R, pain transmission, inflammatory diseases, obesity, RPKPQQFFGLM, 33507-63-0, NR-140, NR140
- CAS Number:
- 33507-63-0
- Extra Details:
- Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.
- Immunogen:
- Tachykinin receptors
- Molecular Weight:
- 1347.6
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. <strong>286</strong> 1140 PMID: 9732370</p><p>Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. <strong>114</strong> 1343 PMID: 7541689 </p><p>Zieglgänsberger (2019) Substance P and pain chronicity. Cell Tissue Res. <strong>375</strong>(1) 227 https://doi.org/10.1007/s00441-018-2922-y</p>
- Sequence:
- H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid and physiological buffers
- Formula:
- C63H98N18O13S
