Myelin Basic Protein (85-99) peptide antagonist
About this Product
- SKU:
- NR-120
- Additional Names:
- J5|MBP (85-99) peptide antagonist, J5, myelin basic protein 85-99), HLA-DR2, human leukocyte antigen-DR2), epitope, MBP, autoantigen, multiple sclerosis, MS, 444305-16-2, H-EKPKVEAYKAAAAPA-OH, EKPKVEAYKAAAAPA, NR-120, NR120
- CAS Number:
- 444305-16-2
- Extra Details:
- MBP (85-99) peptide antagonist, or J5, is a 15 amino acid peptide fragment designed on the binding motif of MBP 85-99 (myelin basic protein 85-99) to HLA-DR2 (human leukocyte antigen-DR2), which competes with and inhibits the binding of MBP (85-99) to HLA-DR2 and IL-2. MBP 85-99 is the the immunodominant epitope of MBP and a major candidate autoantigen in multiple sclerosis (MS), making this peptide a useful tool for MS research.
- Immunogen:
- Epitopes
- Molecular Weight:
- 1543.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Smith et al (2005) Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis <strong>102</strong>(27) 9595 DOI: 10.1073/pnas.0504131102 </p><p>Stern (2005) Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis <strong>102</strong>(5) 1620 DOI: 10.1073/pnas.0409022102 </p><p>Fridkis-Hareli (2013) Design of peptide immunotherapies for MHC Class-II-associated autoimmune disorders. Clin. Dev. Immunol. 2013<strong> 826</strong>191 https://doi.org/10.1155/2013/826191</p>
- Sequence:
- H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store frozen and desiccated in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Solubility:
- Soluble in dilute acid
- Formula:
- C70H114N18O21
