Kisspeptin 10 (human)
Product Sizes
Kisspeptin 10 (human)
£94.00
NR-050
About this Product
- SKU:
- NR-050
- Additional Names:
- Metastin (45-54)
- CAS Number:
- 374675-21-5
- Extra Details:
- Kisspeptin 10 (human) is a potent endogenous ligand for the kisspeptin receptor (KISS1, GPR54). Kisspeptin 10 (human) binds with high affinity to rat and human KISS1 receptors, with Ki values of 1.59 and 2.33 nM respectively. Kisspeptin 10 (human) has recently emerged as a key regulator of the mammalian reproductive axis while stimulation of GPR54 can also up-regulate proapoptotic genes which have tumour suppressor properties, inhibiting metastasis and invasion in mouse melanomas
- Molecular Weight:
- 1302.5
- Purity:
- >95% by HPLC
- References:
- <p>Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. <strong>276 </strong>34631 <a href="https://pubmed.ncbi.nlm.nih.gov/11457843/" target="_blank" rel="nofollow">PMID: 11457843</a></p><p>Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. <strong>326</strong> 677 <a href="https://pubmed.ncbi.nlm.nih.gov/15596153/" target="_blank" rel="nofollow">PMID: 15596153</a></p><p>Clarke et al (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and metabolism (Seoul, Korea) <strong>30</strong>(2) 124 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508256/" target="_blank" rel="nofollow">PMID: 26194072</a></p><p><a href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1283" target="_blank" rel="nofollow">Guide to Pharmacology - Kisspeptin 10 (human)</a><br></p>
- Sequence:
- H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store frozen and desiccated in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C63H83N17O14