[Leu144, Arg147]-PLP (139-151)
About this Product
- SKU:
- NR-040
- Additional Names:
- [Leu144, Arg147]-PLP (139-151), 188859-65-6, T-cell receptor antagonist, autoimmune disease model experimental allergic encephalomyelitis, EAE, H-HSLGKLLGRPDKF-OH, HSLGKLLGRPDKF, NR-040, NR040
- CAS Number:
- 188859-65-6
- Extra Details:
- [Leu144, Arg147]-PLP (139-151) is an analogue of PLP (139-151) which can act as a T-cell receptor antagonist, able to prevent development of the autoimmune disease model experimental allergic encephalomyelitis (EAE). [Leu144, Arg147]-PLP (139-151 prevents EAE when co-administered with native PLP(139-151) and can limit progression of EAE if given early after the onset of disease in mice.
- Immunogen:
- Epitopes
- Molecular Weight:
- 1467.7
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Ruiz et al (1999) Suppressive Immunization with DNA Encoding a Self-Peptide Prevents Autoimmune Disease: Modulation of T Cell Costimulation J. Immunol. (1999) <strong>16</strong>2(6) 3336 DOI: 10.4049/jimmunol.175.8.4935 </p><p>Anderton (2001) Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology <strong>104</strong>(4) 367 doi:10.1046/j.1365-2567.2001.01324.x </p><p>Potolicchio et al (2005) Conformational Variation of Surface Class II MHC Proteins during Myeloid Dendritic Cell Differentiation Accompanies Structural Changes in Lysosomal MIIC. J. Immunol. <strong>175</strong> 4935 DOI: 10.4049/jimmunol.175.8.4935</p>
- Sequence:
- H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C67H110N20O17
