PLP (139-151)
About this Product
- SKU:
- NR-030
- Additional Names:
- PLP (139-151), proteolipid protein (139-151), myelin proteolipid protein, PLP, Myelin, experimental allergic encephalomyelitis, EAE, multiple sclerosis, MS, 131334-43-5, HCLGKWLGHPDKF, NR-030, NR030|Proteolipid protein (139-151)
- CAS Number:
- 131334-43-5
- Extra Details:
- PLP (139-151), or proteolipid protein (139-151) is a myelin proteolipid protein (PLP) fragment. PLP is one of the major protein constituents of myelin, along with myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP), which between them make up 15% - 25% of dry weight, the rest being mainly lipids. Myelin has an essential insulating role for nerves, allowing normal motor function, sensory function and cognition. Animals immunized with PLP (139-151) develop severe experimental allergic encephalomyelitis (EAE) and this model is widely used to study human multiple sclerosis (MS).
- Immunogen:
- Epitopes
- Molecular Weight:
- 1537.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol.<strong> 142</strong> 1523 <a href="https://pubmed.ncbi.nlm.nih.gov/2465343/" target="_blank" rel="nofollow">PMID: 2465343</a></p><p>Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology <strong>59</strong> 305 <a href="https://pubmed.ncbi.nlm.nih.gov/1716908/" target="_blank" rel="nofollow">PMID: 1716908</a></p><p>Tigno-Aranjuez et al (2009) Encephalitogenicity of Complete Freund's Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells. J. Immunol. <strong>183</strong>(9) 5654 <a href="https://pubmed.ncbi.nlm.nih.gov/19812193/" target="_blank">PMID: 19812193</a></p>
- Sequence:
- H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C72H104N20O16S
