MOG (35-55) (human)
About this Product
- SKU:
- NR-010
- Additional Names:
- MOG (35-55) (human), human myelin oligodendrocyte glycoprotein, MOG, myelin sheath, experimental autoimmune encephalomyelitis, encephalitogenic, EAE, 163158-19-8, H-MEVGWYRPPFSRVVHLYRNGK-OH, MEVGWYRPPFSRVVHLYRNGK, NR-010, NR010
- CAS Number:
- 163158-19-8
- Extra Details:
- MOG (35-55) (human) is a truncated fragment of human myelin oligodendrocyte glycoprotein (MOG), the transmembrane glycoprotein expressed at the surface of oligodendrocyte cells and on the outermost surface of the myelin sheath, which can be used for the induction of experimental autoimmune encephalomyelitis in mouse and rat models. In contrast to MOG (35-55) (rat), Mog (35-55) (human) is only weakly encephalitogenic but both induce antibodies that are equivalent in titer and IgG subclass, demonstrating that EAE can be induced in C57BL/6 mice by two different mechanisms
- Immunogen:
- Epitopes
- Molecular Weight:
- 2592
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Oliver et al (2003) Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. J. Immunol. <strong>171</strong> (1) 462 <a href="https://pubmed.ncbi.nlm.nih.gov/12817031/" target="_blank" rel="nofollow">PMID: 12817031</a></p><p>Haas et al (2005) Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. <strong>35</strong>(11) 3343<a href="https://pubmed.ncbi.nlm.nih.gov/16206232/" target="_blank"> PMID: 16206232</a></p>
- Sequence:
- H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dark, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C120H179N35O28S
