Endomorphin-2
About this Product
- SKU:
- MO-020
- Additional Names:
- EM-2|Endomorphin-2, Endomorphin-2, Endomorphin2, 141801-26-5, EM-2, H-Tyr-Pro-Phe-Phe-NH2, MO-020, MO020
- CAS Number:
- 141801-26-5
- Extra Details:
- Endomorphin-2 is an endogenous peptide with extremely high affinity and selectivity for u-opioid receptors, with Ki values of 0.69, 9233 and 5240 nM for u, D Delta and K Kappa receptors respectively. Endomorphin-2 is one of the two endomorphins and along with endomorphin-1 produces analgesia in animals, but whereas endomorphin-1 is more prevalent in the brain, endomorphin-2 is more prevalent in the spinal cord.
- Immunogen:
- μ Opioid receptors
- Molecular Weight:
- 571.65
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature <strong>386</strong> 499 PMID: 9087409</p><p>Okutsu et al (2006) Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology <strong>31</strong> 375 https://doi.org/10.1038/sj.npp.1300804<br></p><p>Rivero et al (2012). Endomorphin-2: a biased agonist at the μ-opioid receptor. Molecular Pharmacology <strong>82</strong>(2) 178 https://doi.org/10.1124/mol.112.078659</p>
- Sequence:
- H-Tyr-Pro-Phe-Phe-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 0.40 mg/ml in water
- Formula:
- C32H37N5O5
