PAMP 20 (human)
About this Product
- SKU:
- MG-020
- Additional Names:
- PAMP-20 (human), PAMP 20 (human), MG-020, 150238-87-2, ARLDVASEFRKKWNKWALSR-NH2, ARLDVASEFRKKWNKWALSR, Proadrenomedullin N-terminal 20 peptide, PAMP (1-20)|Proadrenomedullin N-terminal 20 peptide, PAMP (1-20)
- CAS Number:
- 150238-87-2
- Extra Details:
- PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
- Immunogen:
- Mas-related G protein-coupled receptors,Antibacterials
- Molecular Weight:
- 2460.87
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Mahata et al (1998) Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension <strong>32</strong> 907 <a href="https://pubmed.ncbi.nlm.nih.gov/9822452/" target="_blank" rel="nofollow">PMID: 9822452</a></p><p>Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 330(4) 1146 <a href="https://pubmed.ncbi.nlm.nih.gov/15823563/" target="_blank" rel="nofollow">PMID: 15823563</a><br></p><p>Ajish (2020) Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism. Biochem Biophys Res Commun. <strong>527</strong>(3) 744 <a href="https://pubmed.ncbi.nlm.nih.gov/32439180/" target="_blank">PMID: 32439180</a></p>
- Sequence:
- H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C112H178N36O27
