PAMP 12 (human, porcine)
About this Product
- SKU:
- MG-010
- Additional Names:
- PAMP (9-20)|PAMP-12 (human, porcine), PAMP 12, MG-010, 196305-05-2, FRKKWNKWALSR-NH2, FRKKWNKWALSR, PAMP (9-20)
- CAS Number:
- 196305-05-2
- Extra Details:
- PAMP 12 (human, porcine) corresponds to amino acids 9 to 20 of proadrenomedullin. and is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 57.2 nM. PAMP 12 (human, porcine) can cause hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP 12 (human, porcine) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
- Immunogen:
- Mas-related G protein-coupled receptors,Antibacterials
- Molecular Weight:
- 1618.95
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Kuwasako (1997) Purification and characterization of PAMP-12 (PAMP[9-20]) in porcine adrenal medulla as a major endogenous biologically active peptide. FEBS Lett. <strong>414</strong>(1) 105 <a href="https://pubmed.ncbi.nlm.nih.gov/9305741/" target="_blank" rel="nofollow">PMID: 9305741</a></p><p>Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. <strong>330</strong> 1146 <a href="https://pubmed.ncbi.nlm.nih.gov/15823563/" target="_blank" rel="nofollow">PMID: 15823563</a></p><p>Ajish (2020) Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism. Biochem Biophys Res Commun. <strong>527</strong>(3) 744 <a href="https://pubmed.ncbi.nlm.nih.gov/32439180/" target="_blank" rel="nofollow">PMID: 32439180</a></p><p><a href="https://pubchem.ncbi.nlm.nih.gov/compound/16137959" target="_blank">PubChem record - PAMP-12 (human, porcine)</a></p>
- Sequence:
- H-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C77H119N25O14
